DNA binding properties and biological studies of cis-dichloro tetrakis(dimethylsulphoxide)ruthenium(II) complex
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چکیده
The [Ru(DMSO)4Cl2] is a well known compound among the ruthenium complexes. Here, we report a unique binding of this compound with Calf Thymus DNA (CT-DNA) by spectroscopic and electrophoresis studies. The biological studies of this compound carried out in vivo and in vitro experiments on mice bearing with Dalton’s lymphoma were performed. The six co-ordinated [Ru(DMSO)4Cl2] complex was prepared and the structure has been characterized by FT-IR, H NMR and x-ray diffraction studies. The evidences of DNA binding by this complex have been indicated from fluorescence, UV-visible and electrophoresis studies. Also, the anticancer property of this complex against Dalton’s Lymphoma is found interesting.
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تاریخ انتشار 2012